PROBer is a program to quantify chemical modification profiles for a general set of sequencing-based ‘toeprinting’ assays, which aim at probing RNA structures (DMS/SHAPE-seq), detecting RNA modifications (Pseudo-seq), and investigating RNA-protein interactions (iCLIP).

The project was a collaboration of Bo Li, Akshay Tambe, Sharon Aviran, and Lior Pachter.

To use PROBer,   download the software and visit the Getting started page.